Article
Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer.
International journal of cancer - 15 May 1994
Tsuda H, Hirohashi S
Abstract excerpt
In order to reveal whether differences in the type and site of p53 gene mutations influence the function of the gene and tumor phenotype, we examined nuclear accumulation of the p53 protein immunohistochemically, loss of the other p53 allele by restriction-fragment-length polymorphism analysis, a...
Topics
- Alleles
- Base Sequence
- Breast Neoplasms
- Cell Nucleus
- Chromosomes, Human, Pair 17
- Female
- Frameshift Mutation
- Gene Deletion
- Gene Expression
- Genes, p53
- Humans
- Immunohistochemistry
- Molecular Sequence Data
- Nuclear Proteins
- Phenotype
- Point Mutation
- Polymorphism, Restriction Fragment Length
- Tumor Suppressor Protein p53