Article
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991
Gaidano G, Ballerini P, Gong J Z, Inghirami G, Neri A, Newcomb E W, Magrath I T, Knowles D M, Dalla-Favera R
Abstract excerpt
We have investigated the frequency of p53 mutations in B- and T-cell human lymphoid malignancies, including acute lymphoblastic leukemia, the major subtypes of non-Hodgkin lymphoma, and chronic lymphocytic leukemia. p53 exons 5-9 were studied by using genomic DNA from 197 primary tumors and 27 ce...
Topics
- Base Sequence
- Burkitt Lymphoma
- Electrophoresis, Polyacrylamide Gel
- Humans
- Leukemia, B-Cell
- Leukemia, Lymphocytic, Chronic, B-Cell
- Leukemia, T-Cell
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Tumor Suppressor Protein p53