Article
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991
Gaidano G, Ballerini P, Gong J Z, Inghirami G, Neri A, Newcomb E W, Magrath I T, Knowles D M, Dalla-Favera R
Abstract excerpt
We have investigated the frequency of p53 mutations in B- and T-cell human lymphoid malignancies, including acute lymphoblastic leukemia, the major subtypes of non-Hodgkin lymphoma, and chronic lymphocytic leukemia. p53 exons 5-9 were studied by using genomic DNA from 197 primary tumors and 27 cell lines by single-strand conformation polymorphism analysis and by direct sequencing of PCR-amplified fragments....
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