Article

The Degree of Polymerization and Sulfation Patterns in Heparan Sulfate are Critical Determinants of Cytomegalovirus Entry into Host Cells

2019-03-26

Abstract excerpt

<h4>ABSTRACT</h4> Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host membrane fusion and virus entry. Interfering with HS-herpesvirus interactions has long been known to result in significant reduction in virus infectivity indicating that HS p...

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Literature Corpus work: 89c367f8-8bae-580e-9ea3-d5ddd86ed37d
DOI: 10.1101/590463

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