Article

Galectin-3-binding protein inhibits extracellular heparan 6- <i>O</i> -endosulfatse Sulf-2

2023-12-21

Abstract excerpt

Human extracellular 6- O -endosulfatases Sulf-1 and Sulf-2 are the only enzymes that post-synthetically alter the 6- O sulfation of heparan sulfate proteoglycans (HSPG), which regulates interactions of HSPG with many proteins. Oncogenicity of Sulf-2 in different cancers has been documented and we have shown that Sulf-2 is associated with poor survival outcomes in head and neck squamous cell carcinoma (HNSCC). In...

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Literature Corpus work: 48791ed2-f5f2-5165-985d-1d625bab1751
DOI: 10.1101/2023.12.20.572603

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