Article
Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity.
Molecules (Basel, Switzerland) - 14 Sept 2020
Annaval Thibault, Wild Rebekka, Crétinon Yoann, Sadir Rabia, Vivès Romain R, Lortat-Jacob Hugues
Abstract excerpt
Glycosylation is a common and widespread post-translational modification that affects a large majority of proteins. Of these, a small minority, about 20, are specifically modified by the addition of heparan sulfate, a linear polysaccharide from the glycosaminoglycan family. The resulting molecules, heparan sulfate proteoglycans, nevertheless play a fundamental role in most biological functions by interacting with...
Topics
- Animals
- Cell Membrane
- Extracellular Matrix
- Glycosaminoglycans
- Glycosylation
- Golgi Apparatus
- Heparan Sulfate Proteoglycans
- Heparitin Sulfate
- Humans
- Mutation
- Oligosaccharides
- Protein Biosynthesis
- Protein Domains