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Article

An animal cell mutant defective in heparan sulfate hexuronic acid 2-O-sulfation.

The Journal of biological chemistry - 26 Jul 1996

Bai X, Esko J D

Abstract excerpt

The interaction of heparan sulfate with protein ligands depends on unique oligosaccharide sequences containing iduronic acid (IdUA), N-sulfated glucosamine residues, and O-sulfated sugars. To study the role of O-sulfation in greater detail, we isolated a Chinese hamster ovary cell mutant defective in 2-O-sulfation of iduronic acid. The mutant, pgsF-17, was identified by a colony blotting assay in which colonies...

Topics

Animals
CHO Cells
Carbohydrate Sequence
Cricetinae
Disaccharides
Glucuronates
Glucuronic Acid
Heparitin Sulfate
Iduronic Acid
Molecular Sequence Data
Mutation
Sulfotransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 8663454
DOI: 10.1074/jbc.271.30.17711

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