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Article

Heparan sulfate proteoglycans in healthy and diseased systems.

Wiley interdisciplinary reviews. Systems biology and medicine - 1 Jan 2000

Whitelock John, Melrose James

Abstract excerpt

Heparin and heparan sulfate (HS) are glycosaminoglycans (GAGs) that are synthesized in the tissues and organs of mammals. They are synthesized and attached to a core protein as proteoglycans through serine-glycine concensus motifs along the core protein. These GAGs are linear polysaccharides composed of repeating disaccharide saccharide units that are variously modified along their length. As a consequence of...

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PMID: 21462353
DOI: 10.1002/wsbm.149

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