Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase.

Scientific reports - 7 Aug 2018

Thieker David F, Xu Yongmei, Chapla Digantkumar, Nora Chelsea, Qiu Hong, Felix Thomas, Wang Lianchun, Moremen Kelley W, Liu Jian, Esko Jeffrey D, Woods Robert J

Abstract excerpt

Heparan Sulfate (HS) is a cell signaling molecule linked to pathological processes ranging from cancer to viral entry, yet fundamental aspects of its biosynthesis remain incompletely understood. Here, the binding preferences of the uronyl 2-O-sulfotransferase (HS2ST) are examined with variably-sulfated hexasaccharides. Surprisingly, heavily sulfated oligosaccharides formed by later-acting sulfotransferases bind...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Cricetulus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucosamine

Share to Heparitin Sulfate

Share to Molecular Docking Simulation

Share to Oligosaccharides

Share to Sulfates

Share to Sulfotransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 30087361
DOI: 10.1038/s41598-018-29602-4
PMCID: PMC6081452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase.PMID 30087361Read ↗

Role of heparan sulfate in sexually transmitted infectionsSemantic proximity Read ↗

Heparan sulfate proteoglycans.Semantic proximity Read ↗

Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutants.Semantic proximity Read ↗

The Degree of Polymerization and Sulfation Patterns in Heparan Sulfate are Critical Determinants of Cytomegalovirus Entry into Host CellsSemantic proximity Read ↗

Structure of the human heparan sulfate polymerase complex EXT1-EXT2Semantic proximity Read ↗

Galectin-3-binding protein inhibits extracellular heparan 6- <i>O</i> -endosulfatse Sulf-2Semantic proximity Read ↗

QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling.Semantic proximity Read ↗

Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1.Semantic proximity Read ↗

Chemical biology tools for structure-function studies on heparan sulphates : decoding specificity in FGF signallingSemantic proximity Read ↗

Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.Semantic proximity Read ↗

Role of heparan sulfate-2-O-sulfotransferase in the mouse.Semantic proximity Read ↗

Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.