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Article

Analysis of the p300/CBP-Associated Factor (PCAF) gene in astrocytic tumors.

Journal of neuro-oncology - 1 Jan 2000

Nishimori H, Nishikawa R, Fujimaki T, Nakagomi T, Matsutani M, Huang H J, Cavenee W K

Abstract excerpt

The PCAF gene encodes the p300/CBP-Associated Factor (PCAF), a histone acetyltransferase, which regulates p53 by acetylation of Lys320 in the C-terminal portion of p53. While the p53 gene is one of the most frequently mutated tumor suppressor genes in human tumors, such mutations occur in only 30% of astrocytic tumors. Since PCAF can regulate p53 activity, abrogation of PCAF function by PCAF gene mutation could...

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Source

Identifiers

PMID: 10896202
DOI: 10.1023/a:1006404110073

Genes

AGT
GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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