Article
Comparative study of p53 gene and protein alterations in human astrocytic tumors.
Journal of neuropathology and experimental neurology - 1 Jan 1993
Louis D N, von Deimling A, Chung R Y, Rubio M P, Whaley J M, Eibl R H, Ohgaki H, Wiestler O D, Thor A D, Seizinger B R
Abstract excerpt
The p53 gene is a tumor suppressor gene involved in many common malignancies, including astrocytomas. Genetic analysis of the p53 gene and immunohistochemistry of the p53 protein have each been used to screen astrocytomas. To compare these methods, we performed immunohistochemistry with the monoc...
Topics
- Adolescent
- Adult
- Aged
- Amino Acid Sequence
- Astrocytoma
- Brain Neoplasms
- Child
- Codon
- Exons
- Female
- Glioblastoma
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic