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Article

Comparative study of p53 gene and protein alterations in human astrocytic tumors.

Journal of neuropathology and experimental neurology - 1 Jan 1993

Louis D N, von Deimling A, Chung R Y, Rubio M P, Whaley J M, Eibl R H, Ohgaki H, Wiestler O D, Thor A D, Seizinger B R

Abstract excerpt

The p53 gene is a tumor suppressor gene involved in many common malignancies, including astrocytomas. Genetic analysis of the p53 gene and immunohistochemistry of the p53 protein have each been used to screen astrocytomas. To compare these methods, we performed immunohistochemistry with the monoclonal antibody PAb 1801 and single-strand conformational polymorphism (SSCP) with sequence analysis on 34 astrocytic...

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Identifiers

PMID: 8381161
DOI: 10.1097/00005072-199301000-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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