Frequency of p53 tumor suppressor gene mutations in human primary brain tumors.

doi:10.1227/00006123-199311000-00006

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Article

Frequency of p53 tumor suppressor gene mutations in human primary brain tumors.

Neurosurgery - 1 Nov 1993

Wu J K, Ye Z, Darras B T

Abstract excerpt

Mutations in the p53 tumor suppressor gene are the most common genetic alterations found in diverse types of human cancer, including the primary malignant brain tumor, glioblastoma multiforme. To estimate the frequency of p53 mutations in human brain tumors, we screened 120 human primary brain tu...

Topics

Alleles
Astrocytoma
Brain Neoplasms
Chromosome Aberrations
Chromosomes, Human, Pair 17
Genes, Tumor Suppressor
Genes, p53
Glioblastoma
Humans
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

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