Reappraisal of p53 mutations in human malignant astrocytic neoplasms by p53 functional assay: comparison with conventional structural analyses.

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Article

Reappraisal of p53 mutations in human malignant astrocytic neoplasms by p53 functional assay: comparison with conventional structural analyses.

Molecular carcinogenesis - 1 Mar 1997

Tada M, Iggo R D, Waridel F, Nozaki M, Matsumoto R, Sawamura Y, Shinohe Y, Ikeda J, Abe H

Abstract excerpt

We previously reported clonal expansion of p53 mutations in malignant astrocytic tumors detected with a yeast p53 functional assay that measures mutant p53 alleles quantitatively and loss of p53 transcriptional competence qualitatively (Tada et al., Int J Cancer 67:447-450, 1996). This method sel...

Topics

Adult
Aged
Alleles
Artifacts
Astrocytoma
Base Composition
Brain Neoplasms
Child
Codon
DNA Transposable Elements
Female
Genes, p53
Glioblastoma
Humans
Male
Middle Aged
Mutation
Point Mutation

Source

Open in PubMed

Identifiers

PMID: 9115587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9115587-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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