Article
The p73 gene is not mutated in oligodendrogliomas which frequently have a deleted region at chromosome 1p36.3.
Anticancer research - 1 Jan 2000
Tsujimoto T, Mochizuchi S, Iwadate Y, Namba H, Nagai M, Kawamoto T, Sunahara M, Yamaura A, Nakagawara A, Sakiyama S, Tagawa M
Abstract excerpt
An allelic loss of the chromosome 1p36 region is frequently found in oligodendrogliomas, which suggests the presence of putative tumor suppressor gene(s) in the region. Since the p73 gene, which encodes a protein with significant homology with p53, is mapped to the 1p36.33 region, we examined genetic alterations of the p73 gene in oligodendrogliomas. We screened 10 specimens for mutation throughout the p73 coding...
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