Article
Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay.
International journal of cancer - 10 Jun 1998
Ishii N, Sawamura Y, Tada M, Daub D M, Janzer R C, Meagher-Villemure M, de Tribolet N, Van Meir E G
Abstract excerpt
Although p53-gene mutations occur with significant frequency in diffuse low-grade and high-grade astrocytomas, and are postulated to play an important role in tumorigenesis in these cases, the role of the p53 gene in pilocytic astrocytomas remains unclear. Published data using DNA-based assays for p53-gene analysis in these tumors have shown contradictory results in mutation frequency (0-14%). It is not known...
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