Article
Expression and mutation analysis of the p53 gene in astrocytoma.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Jan 1999
Hwang S L, Hong Y R, Sy W D, Chai C Y, Lin H J, Howng S L
Abstract excerpt
The role of p53 gene mutations in the formation or progression of human astrocytic tumors is controversial. We studied the distribution pattern of p53 immunoreactivity and analyzed p53 gene mutations to define the significance of p53 gene mutations in astrocytoma tumorigenesis or malignant progression. Twenty-three astrocytic tumors were evaluated with immunohistochemistry, single-strand conformation polymorphism...
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