Mutation analysis of the p73 gene in nonastrocytic brain tumours.

doi:10.1054/bjoc.2001.1855

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Article

Mutation analysis of the p73 gene in nonastrocytic brain tumours.

British journal of cancer - 20 Jul 2001

Alonso M E, Bello M J, Gonzalez-Gomez P, Lomas J, Arjona D, de Campos J M, Kusak M E, Sarasa J L, Isla A, Rey J A

Abstract excerpt

Loss of heterozygosity (LOH) involving the distal chromosome 1 p36 region occurs frequently in nonastrocytic brain tumours, but the tumour suppressor gene targeted by this deletion is unknown. p73 is a novel gene that has high sequence homology and similar gene structure to the p53 gene; it has been mapped to 1 p36, and may thus represent a candidate for this tumour suppressor gene. To determine whether p73 is...

Topics

Brain Neoplasms
Chromosomes, Human, Pair 1
DNA-Binding Proteins
Genes, Tumor Suppressor
Humans
Loss of Heterozygosity
Mutation
Nuclear Proteins
Polymorphism, Single-Stranded Conformational
Tumor Protein p73
Tumor Suppressor Proteins

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Identifiers

PMID: 11461077
DOI: 10.1054/bjoc.2001.1855
PMCID: PMC2364057

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