Infrequent mutation of Waf1/p21 gene, a CDK inhibitor gene, in brain tumors.

doi:10.2176/nmc.37.150

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Article

Infrequent mutation of Waf1/p21 gene, a CDK inhibitor gene, in brain tumors.

Neurologia medico-chirurgica - 1 Feb 1997

Tsumanuma I, Tanaka R, Abe S, Kawasaki T, Washiyama K, Kumanishi T

Abstract excerpt

Possible mutations of the Waf1/p21 gene, a cyclin-dependent kinase (CDK) inhibitor gene, were investigated in biopsy specimens of 28 brain tumors using polymerase chain reaction (PCR)-single strand conformation polymorphism and nucleotide sequence analysis. There were 15 astrocytic tumors, six me...

Topics

Adolescent
Adult
Aged
Astrocytoma
Brain Neoplasms
Child
Child, Preschool
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Female
Humans
Infant
Male
Medulloblastoma
Middle Aged
Mutation
Polymerase Chain Reaction

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