Article
Rare occurrence of inactivating p53 gene mutations in primary non-astrocytic tumors of the central nervous system: reappraisal by yeast functional assay.
Acta neuropathologica - 1 Mar 1998
Nozaki M, Tada M, Matsumoto R, Sawamura Y, Abe H, Iggo R D
Abstract excerpt
While it is established that p53 mutation plays a critical role in the carcinogenesis of astrocytic brain tumors, its role remains to be clarified for other types of tumors in the central nervous system (CNS). Using a yeast-based assay which tests the ability of human p53 to activate transcriptio...
Topics
- Adolescent
- Adult
- Aged
- Base Sequence
- Brain Neoplasms
- Child
- Child, Preschool
- DNA Mutational Analysis
- Ependymoma
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Techniques