Article
p53 gene mutations in human astrocytic brain tumors including pilocytic astrocytomas.
Human pathology - 1 Jun 1996
Patt S, Gries H, Giraldo M, Cervos-Navarro J, Martin H, Jänisch W, Brockmöller J
Abstract excerpt
Recent molecular biological studies have shown evidence for a distinct pathogenesis of pilocytic astrocytomas based on alterations other than mutations of the tumor suppressor gene p53. To prove these data, the authors screened a series of 42 astrocytic human brain tumors with a relatively high proportion (16.6%) of the pilocytic variant for the presence of p53 mutations, using the polymerase chain reaction (PCR)...
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