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Article

Selective genotyping with epistasis can be utilized for a major quantitative trait locus mapping in hypertension in rats.

Genetics - 1 Jun 2000

Ohno Y, Tanase H, Nabika T, Otsuka K, Sasaki T, Suzawa T, Morii T, Yamori Y, Saruta T

Abstract excerpt

Epistasis used to be considered an obstacle in mapping quantitative trait loci (QTL) despite its significance. Numerous epistases have proved to be involved in quantitative genetics. We established a backcross model that demonstrates a major QTL for hypertension (Ht). Seventy-eight backcrossed rats (BC), derived from spontaneously hypertensive rats (SHR) and normotensive Fischer 344 rats, showed bimodal...

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Share to Chromosome Mapping
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypertension

Share to Quantitative Trait, Heritable

Share to Rats, Inbred F344

Share to Rats, Inbred SHR

Source

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Identifiers

PMID: 10835399
DOI: 10.1093/genetics/155.2.785
PMCID: PMC1461129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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