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Article

Genetic basis of polygenic hypertension

31 Jul 2007

Abstract excerpt

Essential hypertension is a common disorder that leads to significant morbidity and mortality; however, the underlying mechanisms have remained elusive. Recent animal model studies have uncovered a complex genetic architecture of quantitative trait loci (QTLs) for blood pressure (BP), intricate QTL-QTL interactions and powerful genome regulations that underlie polygenic hypertension. BP, a quantitative trait...

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PMID: 17911162
DOI: 10.1093/hmg/ddm126

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