Genetic mechanisms of polygenic hypertension: fundamental insights from experimental models.

doi:10.1097/HJH.0000000000000479

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Article

Genetic mechanisms of polygenic hypertension: fundamental insights from experimental models.

Journal of hypertension - 1 Apr 2015

Deng Alan Y

Abstract excerpt

Essential hypertension is one of the most common disorders that underpin significant morbidity and mortality; however, underlying mechanisms remain elusive that either dictate the actions of individual quantitative trait loci (QTLs) or engineer the overall genetic architecture from them. Recent experimental evidence has unveiled that the genetic architecture determining blood pressure (BP) is assembled from...

Topics

Animals
Blood Pressure
Disease Models, Animal
Essential Hypertension
Humans
Hypertension
Multifactorial Inheritance
Phenotype
Quantitative Trait Loci
Rats
Rats, Inbred Dahl

Source

Open in PubMed

Identifiers

PMID: 25915868
DOI: 10.1097/HJH.0000000000000479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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