Voltage dependent activation of potassium channels is coupled to T1 domain structure.

doi:10.1038/75185

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Article

Voltage dependent activation of potassium channels is coupled to T1 domain structure.

Nature structural biology - 1 May 2000

Cushman S J, Nanao M H, Jahng A W, DeRubeis D, Choe S, Pfaffinger P J

Abstract excerpt

The T1 domain, a highly conserved cytoplasmic portion at the N-terminus of the voltage-dependent K+ channel (Kv) alpha-subunit, is responsible for driving and regulating the tetramerization of the alpha-subunits. Here we report the identification of a set of mutations in the T1 domain that alter the gating properties of the Kv channel. Two mutants produce a leftward shift in the activation curve and slow the...

Topics

Amino Acid Substitution
Animals
Aplysia
Conserved Sequence
Crystallography, X-Ray
Electric Conductivity
Ion Channel Gating
Kinetics
Models, Molecular
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Potassium Channels

Protein Binding

Protein Structure, Quaternary

Protein Structure, Tertiary

Shaker Superfamily of Potassium Channels

Structure-Activity Relationship

Thermodynamics

Source

Open in PubMed

Identifiers

PMID: 10802739
DOI: 10.1038/75185

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