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Article

A positively charged residue at the Kv1.1 T1 interface is critical for voltage-dependent activation and gating kinetics.

American journal of physiology. Cell physiology - 1 Sept 2024

Hasan Sonia Majed, Aswad Nawal, Al-Sabah Suleiman

Abstract excerpt

Within the tetramerization domain (T1) of most voltage-gated potassium channels (Kv) are highly conserved charged residues that line the T1-T1 interface. We investigated the Kv1.1 residue R86 located at the narrowest region of the T1 interface. A Kv1.1 R86Q mutation was reported in a child diagnosed with lower limb dyskinesia (Set KK, Ghosh D, Huq AHM, Luat AF. Mov Disord Clin Pract 4: 784-786, 2017). The child...

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PMID: 39099423
DOI: 10.1152/ajpcell.00422.2024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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