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Article

A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions.

The Journal of biological chemistry - 22 Jul 2005

Gilquin Bernard, Braud Sandrine, Eriksson Mats A L, Roux Benoît, Bailey Timothy D, Priest Birgit T, Garcia Maria L, Ménez André, Gasparini Sylvaine

Abstract excerpt

Animal toxins are associated with well defined selectivity profiles; however the molecular basis for this property is not understood. To address this issue we refined our previous three-dimensional models of the complex between the sea anemone toxin BgK and the S5-S6 region of Kv1.1 (Gilquin, B., Racape, J., Wrisch, A., Visan, V., Lecoq, A., Grissmer, S., Ménez, A., and Gasparini, S. (2002) J. Biol. Chem. 277,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15890656
DOI: 10.1074/jbc.M413626200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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