Article
Interactive domains between pore loops of the yeast K+ channel TOK1 associate with extracellular K+ sensitivity.
The Biochemical journal - 1 Feb 2006
Johansson Ingela, Blatt Michael R
Abstract excerpt
Gating of the outward-rectifying K+ channel TOK1 of Saccharomyces cerevisiae is controlled by membrane voltage and extracellular K+ concentration. Previous studies identified two kinetically distinct effects of K+, and site-mutagenic analysis associated these K+-dependencies with domains of the extracellular turrets of the channel protein. We have mapped the TOK1 pore domains to extant K+ channel crystal...
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