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Article

KCNE1 constrains the voltage sensor of Kv7.1 K+ channels.

PloS one - 9 Apr 2008

Shamgar Liora, Haitin Yoni, Yisharel Ilanit, Malka Eti, Schottelndreier Hella, Peretz Asher, Paas Yoav, Attali Bernard

Abstract excerpt

Kv7 potassium channels whose mutations cause cardiovascular and neurological disorders are members of the superfamily of voltage-gated K(+) channels, comprising a central pore enclosed by four voltage-sensing domains (VSDs) and sharing a homologous S4 sensor sequence. The Kv7.1 pore-forming subunit can interact with various KCNE auxiliary subunits to form K(+) channels with very different gating behaviors. In an...

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Identifiers

PMID: 18398469
DOI: 10.1371/journal.pone.0001943
PMCID: PMC2275793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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KCNE1 constrains the voltage sensor of Kv7.1 K+ channels.PMID 18398469Read ↗

KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.Semantic proximity Read ↗

S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels.Semantic proximity Read ↗

D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence.Semantic proximity Read ↗

Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain.Semantic proximity Read ↗

State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation.Semantic proximity Read ↗

Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel ComplexesSemantic proximity Read ↗

Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1.7.Semantic proximity Read ↗

Chemical tuning reveals a cation-π gating bridge between the voltage-sensor and pore domains in the Kv7.1 potassium channel.Semantic proximity Read ↗

The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel.Semantic proximity Read ↗

Dissection of the structure-function relationship of Nav channels.Semantic proximity Read ↗

KCNE3 acts by promoting voltage sensor activation in KCNQ1.Semantic proximity Read ↗

In silico investigation of the interaction between the voltage-gated potassium channel Kv4.3 and its auxiliary protein KChIP1.Semantic proximity Read ↗

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