Article
A central role for the T1 domain in voltage-gated potassium channel formation and function.
The Journal of biological chemistry - 27 Jul 2001
Strang C, Cushman S J, DeRubeis D, Peterson D, Pfaffinger P J
Abstract excerpt
To interpret the recent atomic structures of the Kv (voltage-dependent potassium) channel T1 domain in a functional context, we must understand both how the T1 domain is integrated into the full-length functional channel protein and what functional roles the T1 domain governs. The T1 domain clearly plays a role in restricting Kv channel subunit heteromultimerization. However, the importance of T1 tetramerization...
Topics
- Animals
- Blotting, Western
- COS Cells
- Cell Membrane
- Dimerization
- Kv1.1 Potassium Channel
- Microscopy, Confocal
- Models, Chemical
- Models, Molecular
- Mutation
- Point Mutation