Article
Answers and questions from the KvAP structures.
Neuron - 31 Jul 2003
Cohen Bruce E, Grabe Michael, Jan Lily Yeh
Abstract excerpt
The recent landmark structures of KvAP, a voltage-gated potassium (Kv) channel, provide the first high-resolution experimental structural models of this class of proteins. Previous extensive studies of Kv channels provide a means to evaluate and interpret the KvAP structures. In this minireview, we survey different experimental approaches to Kv channels and map these findings to KvAP, showing that the...
Topics
- Animals
- Humans
- Ion Channel Gating
- Mutation
- Potassium Channels, Voltage-Gated
- Structure-Activity Relationship