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Article

KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.

Biophysical journal - 1 Dec 2010

Wu Dick, Pan Hua, Delaloye Kelli, Cui Jianmin

Abstract excerpt

The KCNE1 auxiliary subunit coassembles with the Kv7.1 channel and modulates its properties to generate the cardiac I(Ks) current. Recent biophysical evidence suggests that KCNE1 interacts with the voltage-sensing domain (VSD) of Kv7.1. To investigate the mechanism of how KCNE1 affects the VSD to alter the voltage dependence of channel activation, we perturbed the VSD of Kv7.1 by mutagenesis and chemical...

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Source

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Identifiers

PMID: 21112284
DOI: 10.1016/j.bpj.2010.10.018
PMCID: PMC2998620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function.PMID 21112284Read ↗

KCNE1 constrains the voltage sensor of Kv7.1 K+ channels.Semantic proximity Read ↗

D242N, a KV7.1 LQTS mutation uncovers a key residue for IKs voltage dependence.Semantic proximity Read ↗

State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation.Semantic proximity Read ↗

Structural basis of slow activation gating in the cardiac I Ks channel complex.Semantic proximity Read ↗

KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.Semantic proximity Read ↗

ML277 specifically enhances pore opening of KCNQ1 with VSD at the activated state by modulating VSD-pore couplingSemantic proximity Read ↗

Chemical tuning reveals a cation-π gating bridge between the voltage-sensor and pore domains in the Kv7.1 potassium channel.Semantic proximity Read ↗

Dissection of the structure-function relationship of Nav channels.Semantic proximity Read ↗

KCNE3 acts by promoting voltage sensor activation in KCNQ1.Semantic proximity Read ↗

Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel ComplexesSemantic proximity Read ↗

Voltage dependent activation of potassium channels is coupled to T1 domain structure.Semantic proximity Read ↗

Characterization of an LQT5-related mutation in KCNE1, Y81C: implications for a role of KCNE1 cytoplasmic domain in IKs channel function.Semantic proximity Read ↗

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