Dissection of the structure-function relationship of Nav channels.

doi:10.1073/pnas.2322899121

Back to search

Article

Dissection of the structure-function relationship of Nav channels.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2024

Li Zhangqiang, Wu Qiurong, Huang Gaoxingyu, Jin Xueqin, Li Jiaao, Pan Xiaojing, Yan Nieng

Abstract excerpt

Voltage-gated sodium channels (Nav) undergo conformational shifts in response to membrane potential changes, a mechanism known as the electromechanical coupling. To delineate the structure-function relationship of human Nav channels, we have performed systematic structural analysis using human Na...

Topics

Humans
Voltage-Gated Sodium Channels
Membrane Potentials
Mutation
Structure-Activity Relationship

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.