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Article

Dissection of the structure-function relationship of Nav channels.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2024

Li Zhangqiang, Wu Qiurong, Huang Gaoxingyu, Jin Xueqin, Li Jiaao, Pan Xiaojing, Yan Nieng

Abstract excerpt

Voltage-gated sodium channels (Nav) undergo conformational shifts in response to membrane potential changes, a mechanism known as the electromechanical coupling. To delineate the structure-function relationship of human Nav channels, we have performed systematic structural analysis using human Nav1.7 as a prototype. Guided by the structural differences between wild-type (WT) Nav1.7 and an eleven...

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Identifiers

PMID: 38381792
DOI: 10.1073/pnas.2322899121
PMCID: PMC10907234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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