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Article

Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology.

Molecular biology of the cell - 1 May 2000

Ryeom S W, Paul D, Goodenough D A

Abstract excerpt

The tight junction is the most apical intercellular junction of epithelial cells and regulates transepithelial permeability through the paracellular pathway. To examine possible functions for the tight junction-associated protein ZO-1, C-terminally truncated mutants and a deletion mutant of ZO-1 were epitope tagged and stably expressed in corneal epithelial cell lines. Only full-length ZO-1 and one N-terminal...

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Identifiers

PMID: 10793144
DOI: 10.1091/mbc.11.5.1687
PMCID: PMC14876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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