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Article

COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos.

The Journal of cell biology - 25 Aug 1997

Chen Y, Merzdorf C, Paul D L, Goodenough D A

Abstract excerpt

Occludin is the only known integral membrane protein localized at the points of membrane- membrane interaction of the tight junction. We have used the Xenopus embryo as an assay system to examine: (a) whether the expression of mutant occludin in embryos will disrupt the barrier function of tight junctions, and (b) whether there are signals within the occludin structure that are required for targeting to the sites...

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Identifiers

PMID: 9265654
DOI: 10.1083/jcb.138.4.891
PMCID: PMC2138038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos.PMID 9265654Read ↗

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Expression of a dominant negative inhibitor of intercellular communication in the early Xenopus embryo causes delamination and extrusion of cells.Semantic proximity Read ↗

Junctional Complexes in the Early Mammalian EmbryoSemantic proximity Read ↗

Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.Semantic proximity Read ↗

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