Article
An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line.
Experimental animals - 10 Nov 2021
Chen Bing, Wang Hong-Ling, Chen Rui, Chen Li, Yang Shun, Wang Yi, Xue Zheng-Feng
Abstract excerpt
In this study, we describe an N-ethyl-N-nitrosourea-induced mouse model with a corneal opacity phenotype that was associated with "eye open at birth" (EOB). Histological and immunohistochemistry staining analysis showed abnormal differentiation of the corneal epithelial cells in the mutant mice. The EOB phenotype was dominantly inherited on a C57BL/6 (B6) background. This allele carries a T941A substitution in...
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