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Article

Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.

Molecular and cellular biology - 1 Mar 2008

Xu Jianliang, Kausalya P Jaya, Phua Dominic C Y, Ali Safiah Mohamed, Hossain Zakir, Hunziker Walter

Abstract excerpt

ZO-1, ZO-2, and ZO-3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. Even though the zonula occludens (ZO) proteins are among the first TJ proteins to have been i...

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Identifiers

PMID: 18172007
DOI: 10.1128/MCB.00891-07
PMCID: PMC2258782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18172007-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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