Article
Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice.
Eye & contact lens - 1 Jan 2006
Robertson Danielle M, Ladage Patrick M, Yamamoto Nobutaka, Jester James V, Petroll W Matthew, Cavanagh H Dwight
Abstract excerpt
PURPOSE: The antiapoptotic protein Bcl-2 and its proapoptotic counterpart Bax may play an important role in the regulation of corneal epithelial renewal. To understand the physiologic importance of Bcl-2 and Bax in the healthy cornea, epithelial and stromal thickness, proliferation, and surface cell exfoliation rates were examined in the central cornea of genetically altered mice overexpressing Bcl-2 and lacking...
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