Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Formation of tight junction strands by expression of claudin-1 mutants in their ZO-1 binding site in MDCK cells.

Histochemistry and cell biology - 1 Jan 2002

Kobayashi Junichi, Inai Tetsuichiro, Shibata Yosaburo

Abstract excerpt

To investigate the formation mechanism of tight junctions (TJs), we constructed three claudin-1 mutants which varied in their COOH-termini and expressed them in MDCK cells under the control of doxycycline. The differences between these constructs are that a putative ZO-1 binding sequence (KDYV) at the COOH-terminus of claudin-1 was deleted (DeltaCmyc) or present (1CLmyc and DeltaCmycYV), or that a myc-epitope was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Claudin-1
Share to Microscopy, Confocal
Share to Microscopy, Electron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Fragments

Share to Phosphoproteins

Share to Proto-Oncogene Proteins c-myc

Share to Tight Junctions

Share to Zonula Occludens-1 Protein

Source

Identifiers

PMID: 11819095
DOI: 10.1007/s00418-001-0359-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Formation of tight junction strands by expression of claudin-1 mutants in their ZO-1 binding site in MDCK cells.PMID 11819095Read ↗

Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation.Semantic proximity Read ↗

Freeze-fracture electron microscopic study of tight junction strands in HEK293 cells and MDCK II cells expressing claudin-1 mutants in the second extracellular loop.Semantic proximity Read ↗

Functions of claudin tight junction proteins and their complex interactions in various physiological systems.Semantic proximity Read ↗

Claudins in morphogenesis: Forming an epithelial tubeSemantic proximity Read ↗

ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton.Semantic proximity Read ↗

Probing the<i>cis</i>-arrangement of prototype tight junction proteins claudin-1 and claudin-3Semantic proximity Read ↗

Context-Dependent Roles of Claudins in TumorigenesisSemantic proximity Read ↗

Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines.Semantic proximity Read ↗

Tight junction-based epithelial microenvironment and cell proliferation.Semantic proximity Read ↗

Determinants contributing to claudin ion channel formation.Semantic proximity Read ↗

Dysregulated expression of claudins in cancer (Review)Semantic proximity Read ↗

Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.