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Article

ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton.

Molecular biology of the cell - 1 Sept 2009

Van Itallie Christina M, Fanning Alan S, Bridges Arlene, Anderson James M

Abstract excerpt

ZO-1 binds numerous transmembrane and cytoplasmic proteins and is required for assembly of both adherens and tight junctions, but its role in defining barrier properties of an established tight junction is unknown. We depleted ZO-1 in MDCK cells using siRNA methods and observed specific defects in the barrier for large solutes, even though flux through the small claudin pores was unaffected. This permeability...

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Identifiers

PMID: 19605556
DOI: 10.1091/mbc.e09-04-0320
PMCID: PMC2735491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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