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Article

Establishment and characterization of cultured epithelial cells lacking expression of ZO-1.

The Journal of biological chemistry - 22 Oct 2004

Umeda Kazuaki, Matsui Takeshi, Nakayama Mayumi, Furuse Kyoko, Sasaki Hiroyuki, Furuse Mikio, Tsukita Shoichiro

Abstract excerpt

In well polarized epithelial cells, closely related ZO-1 and ZO-2 are thought to function as scaffold proteins at tight junctions (TJs). In epithelial cells at the initial phase of polarization, these proteins are recruited to cadherin-based spotlike adherens junctions (AJs). As a first step to clarify the function of ZO-1, we successfully generated mouse epithelial cell clones lacking ZO-1 expression (ZO-1-/-...

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PMID: 15292177
DOI: 10.1074/jbc.M406563200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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