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Article

Zeb1 mutant mice as a model of posterior corneal dystrophy.

Investigative ophthalmology & visual science - 1 May 2008

Liu Yongqing, Peng Xiaoyan, Tan Jinlian, Darling Douglas S, Kaplan Henry J, Dean Douglas C

Abstract excerpt

PURPOSE: The zinc finger transcription factor Zeb1 binds to E-box-like sequences and is important for maintaining repression of epithelial specification genes in vivo. Overexpression of Zeb1 in cancer triggers epithelial-mesenchymal transition, which facilitates metastasis. The mutation of ZEB1 in humans is linked to posterior polymorphous corneal dystrophy (PPCD), in which an epithelial transition of the corneal...

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Topics

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Share to Bromodeoxyuridine
Share to Collagen Type IV
Share to Corneal Dystrophies, Hereditary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Corneal

Share to Epithelium, Corneal

Share to Fluorescent Antibody Technique, Indirect

Share to Kruppel-Like Transcription Factors

Share to Zinc Finger E-box-Binding Homeobox 1

Source

Open in PubMed Open full text

Identifiers

PMID: 18436818
DOI: 10.1167/iovs.07-0789
PMCID: PMC2504018

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Zeb1 mutant mice as a model of posterior corneal dystrophy.PMID 18436818Read ↗

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Transcriptomic Profiling of Posterior Polymorphous Corneal DystrophySemantic proximity Read ↗

Clinical phenotype of posterior polymorphous corneal dystrophy in a family with a novel ZEB1 mutation.Semantic proximity Read ↗

Analysis of the Role of ZEB1 in the Pathogenesis of Posterior Polymorphous Corneal DystrophySemantic proximity Read ↗

Heterozygous deletions at the ZEB1 locus verify haploinsufficiency as the mechanism of disease for posterior polymorphous corneal dystrophy type 3.Semantic proximity Read ↗

Posterior Polymorphous Corneal Dystrophy in a Patient with a Novel ZEB1 Gene Mutation.Semantic proximity Read ↗

Novel Frameshift Mutation in ZEB1 in a Family with a Severe Form of Posterior Polymorphous Corneal Dystrophy (PPCD)Semantic proximity Read ↗

Identification of six novel mutations in ZEB1 and description of the associated phenotypes in patients with posterior polymorphous corneal dystrophy 3.Semantic proximity Read ↗

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