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Article

Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein.

Molecular and cellular biology - 1 Dec 2006

Adachi Makoto, Inoko Akihito, Hata Masaki, Furuse Kyoko, Umeda Kazuaki, Itoh Masahiko, Tsukita Shoichiro

Abstract excerpt

ZO-1, ZO-2, and ZO-3 are closely related MAGUK family proteins that localize at the cytoplasmic surface of tight junctions (TJs). ZO-1 and ZO-2 are expressed in both epithelia and endothelia, whereas ZO-3 is exclusively expressed in epithelia. In spite of intensive studies of these TJ MAGUKs, our knowledge of their functions in vivo, especially those of ZO-3, is still fragmentary. Here, we have generated mice, as...

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Identifiers

PMID: 17000770
DOI: 10.1128/MCB.01811-05
PMCID: PMC1636814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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