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Article

Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin.

The Journal of cell biology - 21 Feb 2000

Li D, Mrsny R J

Abstract excerpt

Occludin is an integral membrane protein of the epithelial cell tight junction (TJ). Its potential role in coordinating structural and functional events of TJ formation has been suggested recently. Using a rat salivary gland epithelial cell line (Pa-4) as a model system, we have demonstrated that occludin not only is a critical component of functional TJs but also controls the phenotypic changes associated with...

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Identifiers

PMID: 10684259
DOI: 10.1083/jcb.148.4.791
PMCID: PMC2169369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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