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Article

Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.

International journal of oncology - 1 Jul 1999

Orlow I, Rabbani F, Chin L, Pomerantz J, Ligeois N, Dudas M, Depinho R, Cordón-Cardó C

Abstract excerpt

The INK4A and INK4B genes map to 9p21, with the INK4A gene encoding two products, p16 and p19ARF. Many neoplasms in which INK4A and INK4B genes are altered show deletions involving both genes. Mice carrying a targeted Ink4a deletion develop tumors at an early age. In the present study we examined the genetic alterations affecting the remaining Ink4a allele and the Ink4b gene in tumors arising in heterozygous...

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 10375589
DOI: 10.3892/ijo.15.1.17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.PMID 10375589Read ↗

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