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<i>Ink4‐Arf</i> locus in cancer and aging

28 Feb 2012

Abstract excerpt

Three tumor suppressor genes at the small (<50 kb) INK4-ARF (CDKN2A/B) locus on human chromosome 9p21 coordinate a signaling network that depends on the activities of the retinoblastoma (RB) protein and the p53 transcription factor. Disruption of this circuitry, frequently by codeletion of INK4-ARF, is a hallmark of cancer, begging the question of why the intimate genetic linkage of these tumor suppressor genes...

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PMID: 22960768
DOI: 10.1002/wdev.40

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