Article
The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.
Cancer research - 15 Jun 2003
D'Amico Mark, Wu Kongming, Di Vizio Dolores, Reutens Anne T, Stahl Mark, Fu Maofu, Albanese Chris, Russell Robert G, Muller William J, White Michael, Negassa Abdissa, Lee Han-Woong, DePinho Ronald A, Pestell Richard G
Abstract excerpt
Most human tumors display inactivation of the p53 and the p16(INK4)/pRb pathway. The Ink4a/alternative reading frame (ARF) locus encodes the p16(INK4a) and p14(ARF) (murine p19(ARF)) proteins. p16(INK4a) is deleted in 40-60% of breast cancer cell lines, and p16(INK4a) inactivation by DNA methylat...
Topics
- Adenocarcinoma
- Aneuploidy
- Animals
- Apoptosis
- Breast Neoplasms
- Cell Cycle
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Crosses, Genetic
- Cyclin D1
- Cyclin-Dependent Kinase Inhibitor p16
- Female
- Gene Expression Regulation, Neoplastic