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Article

The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.

Cancer research - 15 Jun 2003

D'Amico Mark, Wu Kongming, Di Vizio Dolores, Reutens Anne T, Stahl Mark, Fu Maofu, Albanese Chris, Russell Robert G, Muller William J, White Michael, Negassa Abdissa, Lee Han-Woong, DePinho Ronald A, Pestell Richard G

Abstract excerpt

Most human tumors display inactivation of the p53 and the p16(INK4)/pRb pathway. The Ink4a/alternative reading frame (ARF) locus encodes the p16(INK4a) and p14(ARF) (murine p19(ARF)) proteins. p16(INK4a) is deleted in 40-60% of breast cancer cell lines, and p16(INK4a) inactivation by DNA methylation occurs in < or =30% of human breast cancers. In mice genetically heterozygous for p16(INK4a) or Ink4a/Arf,...

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PMID: 12810676

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