Article
Modeling INK4/ARF tumor suppression in the mouse.
Current molecular medicine - 1 Feb 2007
Berger Justin H, Bardeesy Nabeel
Abstract excerpt
The INK4/ARF locus encodes the p15(INK4B), p16(INK4A) and p14(ARF) tumor suppressor proteins whose loss of function is associated with the pathogenesis of many human cancers. Dissecting the relative contribution of these genes to growth control in vivo is complicated by their physical contiguity and the frequency of homozygous deletions that inactivate all three components of this locus. While genetically...
Topics
- Animals
- Cyclin-Dependent Kinase Inhibitor p16
- Disease Models, Animal
- Humans
- Mice
- Mutation
- Neoplasms
- Tumor Suppressor Proteins