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Article

Aberrant expression of p14 ARF in human cancers: A new biomarker?

1 Jan 2018

Abstract excerpt

The ARF and INK4a genes are located on the same CDKN2a locus, both showing its tumor-suppressive activity. ARF has been shown to monitor potentially harmful oncogenic signalings, making incipient cancer cells undergo senescence or programmed cell death to prevent cancer. On the other hand, INK4a detects both aging and incipient cancer cell signals. The efficiency of detection of oncogenic signals is more...

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Identifiers

PMID: 30740529
DOI: 10.4103/tme.tme_24_17

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