INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

doi:10.1101/gad.13.20.2670

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

Genes & development - 15 Oct 1999

Schmitt C A, McCurrach M E, de Stanchina E, Wallace-Brodeur R R, Lowe S W

Abstract excerpt

The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor development and treatment response, the Emu-myc transgenic lymphoma model was used to generate genetically defined tumors with mutations in the INK4a/ARF, Rb, or p53 genes. Like p53 null lymphomas, INK4a/ARF null lymphomas formed rapidly, were highly invasive,...

Topics

Animals
Antineoplastic Agents
Apoptosis
Drug Resistance
Enhancer Elements, Genetic
Female
Genes, myc
Genes, p16
Genes, p53
Humans
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, B-Cell

Male

Mice

Mice, Inbred C57BL

Mice, Knockout

Mice, Transgenic

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 10541553
DOI: 10.1101/gad.13.20.2670
PMCID: PMC317110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10541553-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.PMID 10541553Read ↗

The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.Semantic proximity Read ↗

The INK4a/ARF locus in murine tumorigenesis.Semantic proximity Read ↗

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis.Semantic proximity Read ↗

INK4a/ARF: a multifunctional tumor suppressor locus.Semantic proximity Read ↗

Dual Role of the Alternative Reading Frame ARF Protein in CancerSemantic proximity Read ↗

Non-Canonical Functions of the ARF Tumor Suppressor in Development and TumorigenesisSemantic proximity Read ↗

Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development.Semantic proximity Read ↗

Tumor spectrum in ARF-deficient mice.Semantic proximity Read ↗

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.Semantic proximity Read ↗

p19 <sup>Arf</sup> induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformationSemantic proximity Read ↗

The ARF Tumor Suppressor Can Promote the Progression of Some TumorsSemantic proximity Read ↗

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.