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Article

INK4a/ARF: a multifunctional tumor suppressor locus.

Mutation research - 25 Aug 2005

Sharpless Norman E

Abstract excerpt

The INK4a/ARF locus encodes two physically linked tumor suppressor proteins, p16(INK4a) and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic relationship of the open reading frames of these proteins initially fueled speculation that only one of the two was the true tumor suppressor, and loss of the other merely coincidental in cancer. Recent human and mouse genetic data, however,...

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Source

Identifiers

PMID: 15878778
DOI: 10.1016/j.mrfmmm.2004.08.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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