Article
INK4a/ARF: a multifunctional tumor suppressor locus.
Mutation research - 25 Aug 2005
Sharpless Norman E
Abstract excerpt
The INK4a/ARF locus encodes two physically linked tumor suppressor proteins, p16(INK4a) and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic relationship of the open reading frames of these proteins initially fueled speculation that only one of the two was the true tumor suppressor, and loss of the other merely coincidental in cancer. Recent human and mouse genetic data, however,...
Topics
- Amino Acid Sequence
- Animals
- Cyclin-Dependent Kinase Inhibitor p16
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Humans
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Tumor Suppressor Protein p14ARF