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Article

The ARF tumor suppressor: Structure, functions and status in cancer

14 Jun 2010

Abstract excerpt

The INK4b-ARF-INK4a locus encodes two members of the INK4 family of cyclin-dependent kinase inhibitors, p15(INK4b) and p16(INK4a), and a completely unrelated protein called ARF. ARF is a nucleolar protein with unusual structure that exhibits tumor suppressive functions. There is growing evidence that ARF signaling is complex, and involves p53-dependent or -independent pathways aiming mainly at restraining...

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Identifiers

PMID: 20549699
DOI: 10.1002/ijc.25511

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The ARF tumor suppressor: Structure, functions and status in cancerPMID 20549699Read ↗

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